| Info. | Vol.4 - No.2 (2010.06.20) |
|---|---|
| Title | A study on cancer-cell invasion based on multi-physics analysis technology |
| Authors | Zhang Linan1 , Jihwan Song1 & Dongchoul Kim1 |
| Institutions | 1Department of Mechanical Engineering, Sogang University, 1 Shinsoo-dong, Mapo-go, Seoul, Korea |
| Abstract | In this paper, a three-dimensional haptotaxis model to simulate the migration of a population of cancer cells has been proposed. The invasion of cancer cells is related with the hapto-attractant and the effect of the interface energies between the cells and the ECM. The diffuse interface model, which incorporates the haptotaxis mechanism and interface energies, is employed. The semi-implicit Fourier spectral scheme is adopted for efficient evaluation of the simulation. The simulation results thoroughly reveal the dynamics of cancer-cell migration. |
| Keyword | Haptotaxis, Cancer cells, Cell migration, Interface energy, Diffuse interface model |
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