| Info. | Vol.5 - No.4 (2011.12.20) |
|---|---|
| Title | Hepatic proteome responses against benz[a]anthracene in the rat |
| Authors | Seul-Ki Park1, Yoo-Na Seo1, Suk-Woo Nam2 & Mi-Young Lee1 |
| Institutions | 1Department of Medical Biotechnology, SoonChunHyang University,
Asan, Chungnam 336-600, Korea
2Department of Pathology, Catholic University, Seoul 137-701, Korea Correspondence and requests for materials should be addressed to M.Y. Lee ( miyoung@sch.ac.kr) |
| Abstract | Benz[a]anthracene (B[a]A) is one of the most ubiquitous polycyclic aromatic hydrocarbons and environmental pollutants. Mass spectrometrybased proteomics was used to characterize changes in the liver proteome in response to B[a]A exposure. Nine hepatic protein spots were identified that exhibited B[a]A-induced significant expression changes. Of these, six were up-regulated and the rest were downregulated by B[a]A at 10% of its LD50. At 50% of the LD50 of B[a]A, five proteins were up-regulated while the rest were down-regulated. The proteomic results were also consistent with those obtained by western blot. The differential expressions of these proteins may allow them to serve as biomarker candidates for B[a]A toxicity. |
| Keyword | Benz[a]anthracene, Rat, Liver, Proteomics, Differential proteins |
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