Info.
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Vol.6 - No.4 (2012.12.20) |
Title
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Water-stable single-walled carbon nanotubes coated by pyrenyl polyethylene glycol for fluorescence imaging and photothermal therapy |
Authors
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Kuewhan Jang1, Kilho Eom2, Gyudo Lee2, Jae-Hee Han3, Seungjoo Haam4, Jaemoon Yang5,
Eunseon Kim6, Woo-Jae Kim6 & Taeyun Kwon2 |
Institutions
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1Department of Mechanical Engineering, Korea University,
Seoul 136-701, Korea
2Department of Biomedical Engineering, Yonsei University,
Wonju 220-710, Korea
3Department of Energy IT, Gachon University, Seongnam,
Gyeonggi-do 461-701, Korea
4Department of Chemical Engineering and Biomolecular Engineering,
Yonsei University, Seoul 120-751, Korea
5Department of Radiology, College of Medicine, Yonsei University,
Seoul 120-752, Korea
6Department of Chemical and Environmental Engineering,
Gachon University, Seongnam, Gyeonggi-do 461-701, Korea
Correspondence and requests for materials should be addressed to
T. Kwon ( tkwon@yonsei.ac.kr) and
W.-J. Kim ( wjkim@gachon.ac.kr) |
Abstract
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Nanomaterials have recently received significant attention as photothermal agents and fluorescence contrast agents for molecular therapeutics due to their unique optical properties (e.g. light absorption). In particular, single-walled carbon nanotubes (SWNTs) have been recently utilized as photothermal agents (for photothermal therapy) because of the solubility of SWNTs as well as their light absorbing capability at the near-infrared region. In this work, we have developed the SWNT-based photothermal agents using pyrene-based PEGylation of SWNTs. FT-IR and/or H-NMR spectroscopies have validated the PEGylation of SWNTs, and it is shown that water-soluble SWNTs are able to generate heat under near-infrared (NIR) irradiation of 5W/cm2. Moreover, it is found that our pyrene-based PEGylated SWNTs exhibit the fluorescence characteristic under the excitation wavelength of 340 nm. Our study sheds light on the pyrenyl PEGylated SWNTs as photothermal agents and/or fluorescence contrast agents for the future applications in molecular therapeutics. |
Keyword
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Single-walled carbon nanotube, Pyrenyl group, Polyethylene glycol, Fluorescence imaging agent, Photothermal therapy |
PDF File
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