| Info. | Vol.10 - No.3 (2016.09.20) |
|---|---|
| Title | Anti-angiogenic Mechanism of IPS-05002, a Novel Antagonist against Integrin 慣5棺1, Determined by ProteoChip-based Antibody Array |
| Authors | Min-A Kim1 & In-Cheol Kang1,2,* |
| Institutions | 1Department of Biological Science, College of Natural Science 2BioChip Research Center, Hoseo University, Asan 31499, Republic of Korea *Correspondence and requests for materials should be addressed to I.-C. Kang ( ickang@office.hoseo.ac.kr) |
| Abstract | IPS-05002, a novel antagonist of integrin 慣5棺1, was screened from a phytochemical compound library using ProteoChip-based integrin 慣5棺1-fibronectin interaction assay method. The novel compound inhibited VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation, adhesion, and migration in a dose-dependent manner. It also suppressed tubular network formation. Differential expression profiling of cell cycle proteins in VEGF-induced HUVECs in the presence of IPS-05002 showed up-regulation of IKB-棺, XRCC4, and down-regulation of Cdc6 compared with HUVECs induced by VEGF alone. In conclusion, these data suggest that IPS-05002 will be a potent inhibitor for VEGF-mediated angiogenesis. |
| Keyword | Integrin, Angiogenesis, Natural products, Small molecule antagonist, VEGF, Antibody microarray |
| PDF File |
 # 2010년도 발행분 부터는 Springer 의 BioChip Journal 페이지에서 전문을 열람하실 수 있습니다.
# 학회회원 로그인 후 [ Springer BioChip Journal 열람하기 ] 버튼을 클릭하시면 새창으로 열립니다. |
