| Info. | Vol.11 - No.1 (2017.03.20) |
|---|---|
| Title | Cholecystokinin as a Potent Diagnostic Marker for Gastric Cancer |
| Authors | Hafeza Akter1,2, Young Sook Yoo1, Won Sang Park3 & Min-Jung Kang1,2,* |
| Institutions | 1Molecular Recognition Research Center, Korea Institute of Scienceand Technology, Seoul 02792, Korea 2Department of Biological Chemistry, Korea University of Science and Technology, Daejeon 34113, Korea 3Department of General Surgery, The Catholic University of Korea, Seoul 06591, Korea *Correspondence and requests for materials should be addressed to M.-J. Kang (mjkang1@kist.re.kr) |
| Abstract | There is no early diagnosis marker for gastric cancer even though the gastric cancer is the second cause of deaths in East Asia. The aim of the current research is to develop a new diagnostic marker of gastric cancer. Commercially available ELISA kits were used to evaluate the peptide levels in plasma collected from Korean healthy and gastric cancer patients. About 1.5 fold decreased plasma cholecystokinin levels were measured in gastric cancer patients (n=75) than in healthy controls (n=36). Plasma cholecystokinin has no age, sex, and disease-dependent variation in control and patients sample. Receiver-operating characteristic curve analysis assessing the performance of cholecystokinin levels as the sensitivity of 94.7% and specificity of 100% compared to healthy controls. These findings suggest plasma cholecystokinin as a useful biomarker for diagnosis of gastric cancer. |
| Keyword | Gastric cancer, Biomarker, ELISA, CCK, Early diagnosis |
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