| Info. | Vol.11 - No.3 (2017.09.20) |
|---|---|
| Title | Integrated miRNA and mRNA Expression Profiling in Response to Eriodictyol in Human Endothelial Cells |
| Authors | Seung Eun Lee1, Hye Rim Park2, Hong Duck Yun2, Jeong-Je Cho1, Hyun-Jong Ahn1, Cheung-Seog Park1 & Yong Seek Park1,* |
| Institutions | 1Department of Microbiology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea 2Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea *Correspondence and requests for materials should be addressed to Y.S. Park (yongseek@khu.ac.kr) |
| Abstract | Eriodictyol, a flavonoid commonly found in citrus fruits, shows neurotrophic, antioxidant, anti- inflammatory, and anti-cancer effects under diverse pathophysiological conditions such as vascular diseases. In this study, we evaluated whether eriodictyol modulates miRNA and mRNA expression. Using microarray analysis, we examined miRNA and mRNA expression in human endothelial cells treated with 10 關M of eriodictyol for 24 h. Using numerous bioinformatic systems, we evaluated the signatures of the potential biological processes and signaling pathways. Our results provide insight into the underlying molecular mechanisms of action of eriodictyol and suggest that eriodictyol can be used for therapeutic intervention in vascular disease. |
| Keyword | Endothelial cells, Eriodictyol, Flavonoid, miRNA, Vascular diseases |
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