| Info. | Vol.12 - No.1 (2018.03.20) |
|---|---|
| Title | Bisphenol A Induces a Distinct Transcriptome Profile in the Male Fish of the Marine Medaka Oryzias javanicus |
| Authors | Bo-Mi Kim1,??/sup>, Ye Jin Jo2,??/sup>, Nayun Lee2, Nayoung Lee2, Seonock Woo2,3, Jae-Sung Rhee4,* & Seungshic Yum2,3,* |
| Institutions | 1Unit of Polar Genomics, Korea Polar Research Institute, Incheon 21990, Republic of Korea 2South Sea Environment Research Center, Korea Institute of Ocean Science and Technology (KIOST), Geoje 53201, Republic of Korea 3Faculty of Marine Environmental Science, University of Science and Technology (UST), Geoje 53201, Republic of Korea 4Department of Marine Science, College of Natural Sciences, Incheon National University, Incheon 22012, Republic of Korea ??/sup>These authors contributed equally to this work. *Correspondence and requests for materials should be addressed to S. Yum (syum@kiost.ac.kr) and J.-S. Rhee (jsrhee@inu.ac.kr) |
| Abstract | While environmental concentration of bisphenol A (BPA) is ubiquitously detected in effluent and surface of freshwater, BPA has also been measured in coastal and marine ecosystems. To understand the effect of waterborne BPA on the transcriptome over time, male fish of the marine medaka Oryzias javanicus were exposed to 76 關g/L of BPA for 72 h. Time-course microarray study identified differentially expressed transcripts upon BPA exposure in the liver tissues in a time-dependent manner. The primary effect of BPA treatment appears to be significantly upregulated mRNA expression of lipid metabolism (e.g. fatty acid process, lipid/lipoprotein biosynthesis and transport, cholesterol regulation), while genes involved in diverse biochemical and physiological processes were downregulated. In particular, vertebrate immunity relevant genes showed strong downregulated patterns across time-courses. This study provides preliminary insights into the transcriptional response of marine medaka male fish to waterborne BPA exposure and suggests a basis for uncovering the mode of action particularly with respect to endocrine disrupting chemicals (EDCs) such as BPA. |
| Keyword | Marine medaka, Oryzias javanicus, Bisphenol A, Microarray, Transcriptome |
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