| Info. | Vol.12 - No.3 (2018.09.20) |
|---|---|
| Title | Impact of Electrical Stimulation on Cortisol Secretion in Rat Adrenal Gland |
| Authors | Manikandan Samidurai1,2,??/sup>, Heekyung Kang1,??/sup>, Vijay S. Ramasamy1,2,* & Jihoon Jo1,2,3,* |
| Institutions | 1NeuroMedical Convergence Lab, Biomedical Research Institute, Chonnam National University Hospital, Jebong-ro, Gwangju 61469, Republic of Korea 2Department of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 61469, Republic of Korea 3Department of Neurology, Chonnam National University Medical School, Gwangju 61469, Republic of Korea ??/sup>These authors contributed equally to this work. *Correspondence and requests for materials should be addressed to J. Jo (Jihoon.Jo@jnu.ac.kr) and V.S. Ramasamy (vijaysankarr@gmail.com) |
| Abstract | Cortisol is the primary hormone responsible for the undesirable effects of stress. This study aimed to understand how electrical stimulation influences cortisol secretion, which can be advantageous for designing future implantable electrical devices, to monitor and control the cortisol level. Acutely prepared adrenal gland slices of Sprague-Dawley rats were electrically stimulated at various frequencies, in the presence and absence of adrenocorticotropic hormone (ACTH) and the resultant cortisol levels determined. Electrical stimulation at ?? Hz frequency inhibited ACTH-induced cortisol secretion, but electrical stimulation alone did not have any effect. Furthermore, when applied in the presence of TTA-P2, a T-type Ca2+ channel inhibitor, electrical stimulation presented no influence on ACTH-induced cortisol secretion. Our results suggest that the inhibition of the T-type Ca2+ channels by electrical stimulation may contribute to its suppression of cortisol secretion. |
| Keyword | Cortisol, Stress, ACTH, Adrenal gland, Electrical stimulation |
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