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(사)한국바이오칩학회 The Korean BioChip Society





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Info. Vol.12 - No.4 (2018.12.20)
Title Fabrication of Multi-layered Macroscopic Hydrogel Scaffold Composed of Multiple Components by Precise Control of UV Energy
Authors Donghyeon Roh1,2, Woongsun Choi1,3, Junbeom Kim1,3, Hyun-Yong Yu1, Nakwon Choi1,4,* & Il-Joo Cho1,4,*
Institutions 1Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea
2School of Electrical Engineering, Korea University, Seoul 02841, Republic of Korea
3Department of Chemical and Biological Engineering, Korea University, Seoul 02841, Republic of Korea
4Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Seoul 02792, Republic of Korea
*Correspondence and requests for materials should be addressed to N. Choi (nakwon.choi@kist.re.kr) and I.-J. Cho (ijcho@kist.re.kr)
Abstract Hydrogel scaffolds composed of multiple components are promising platform in tissue engineering as a transplantation materials or artificial organs. Here, we present a new fabrication method for implementing multi-layered macroscopic hydrogel scaffold composed of multiple components by controlling height of hydrogel layer through precise control of ultraviolet (UV) energy density. Through the repetition of the photolithography process with energy control, we can form several layers of hydrogel with different height. We characterized UV energy-dependent profiles with single-layered PEGDA posts photocrosslinked by the modular methodology and examined the optical effect on the fabrication of multi-layered, macroscopic hydrogel structure. Finally, we successfully demonstrated the potential applicability of our approach by fabricating various macroscopic hydrogel constructs composed of multiple hydrogel layers.
Keyword Photocrosslinking, Macroscopic hydrogel scaffold, Height control via UV energy density, Multilayered structures, Incorporation of multiple components, Tissue engineering, Artificial tissues/organs
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