| Info. | Vol.13 - No.1 (2019.03.20) |
|---|---|
| Title | In Vitro Reconstruction of Brain Tumor Microenvironment |
| Authors | Ilkyoo Koh1 & Pilnam Kim1,* |
| Institutions | 1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea *Correspondence and requests for materials should be addressed to Pilnam Kim (pkim@kaist.ac.kr) |
| Abstract | The cancer cells in brain tumors interact with their microenvironment, which includes stromal cells, the extracellular matrix (ECM), and the physical properties of tissues. The reciprocal interaction between cancer cells and the surrounding microenvironment regulates the biological behavior of cancer cells. To improve our understanding of the progression of brain tumors, it is useful to construct physiologically relevant brain tumor models. Consequently, versatile in vitro tumor models ranging from simplistic twodimensional (2D) cultures to three-dimensional (3D) cultures have been developed to mimic the microenvironments of the brain. This review covers the recent progress in the in vitro reconstruction of brain tumor microenvironments. |
| Keyword | Brain tumor, Microenvironment, In vitro model |
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