| Info. | Vol.13 - No.2 (2019.06.20) |
|---|---|
| Title | Algorithm Analysis of Gas Bubble Generation in a Microfluidic Device |
| Authors | Jang Ho Ha1,†, Hirak Mazumdar2,†, Tae Hyeon Kim1, Jong Min Lee1, Jeong-Geol Na3 & Bong Geun Chung1,* |
| Institutions | 1Department of Mechanical Engineering, Sogang University, Seoul, Republic of Korea, 04107 2Department of Biomedical Engineering, Sogang University, Seoul, Republic of Korea, 04107 3Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Republic of Korea, 04107 †These authors equally contributed to this work *Correspondence and requests for materials should be addressed to B.G. Chung (bchung@sogang.ac.kr) |
| Abstract | We investigated the algorithm analysis of the bubble generation in a microfluidic device to study the effect of the surface tension and the flow rate on the microbubble size. For the analysis of the surface tension, five different solutions were used: 3.5% brine, mineral oil, 1% polyethylene glycol (PEG) 400, 1% tween 80, and 1% triton X-100. The various flow rates were also employed: 5~15 μL/min for the liquid and 100~200 mL/min for the gas phase. The size of the bubble was measured via the algorithm analysis and the bubble defect was also detected by c chart. We observed that the microbubble size was affected by the flow rates of solution and the gas. Hence, we developed an equation to estimate the size through the flow rate ratio between the solution and gas phase, showing that the microbubble size could be controlled by the liquid properties or the flow rates. Therefore, this algorithm-based microfluidic device could be a powerful tool for generating gas microbubbles in a controlled manner. |
| Keyword | Microfluidic device, Algorithm, Gas microbubble, Surface tension, Flow rate |
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