Info.
|
Vol.4 - No.3 (2010.09.20) |
Title
|
Development of three-dimensional haptotaxis model for single crawling cell |
Authors
|
Jihwan Song1 & Dongchoul Kim1
|
Institutions
|
1Department of Mechanical Engineering, Sogang University,
1 Sinsu-dong, Mapo-gu, Seoul, Korea
Correspondence and requests for materials should be addressed to
D. Kim (dckim@sogang.ac.kr)
|
Abstract
|
This paper proposes a three-dimensional diffuse interface dynamic model with multiple mechanisms and confirms the high possibility of adequate predictions. In particular, we consider the nucleus that exhibits three-dimensional motion in the crawling cell, which enables a more realistic representation of haptotactic migration. A diffuse interface model that incor-porates the haptotaxis mechanism and interface energies is employed. The semi-implicit Fourier spectral scheme is adopted for efficient evaluation of the simulation model. The simulation results confirm the reliability of the developed model. |
Keyword
|
Haptotaxis, Sing crawling cell, Cell migration, Morphology, Interface energy, Diffuse interface model
|
PDF File
|
# 2010년도 발행분 부터는 Springer 의 BioChip Journal 페이지에서 전문을 열람하실 수 있습니다.
# 학회회원 로그인 후 [ Springer BioChip Journal 열람하기 ] 버튼을 클릭하시면 새창으로 열립니다.
|