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Info. Vol.4 - No.3 (2010.09.20)
Title Development of three-dimensional haptotaxis model for single crawling cell
Authors Jihwan Song1 & Dongchoul Kim1
Institutions 1Department of Mechanical Engineering, Sogang University, 1 Sinsu-dong, Mapo-gu, Seoul, Korea
Correspondence and requests for materials should be addressed to D. Kim (dckim@sogang.ac.kr)
Abstract This paper proposes a three-dimensional diffuse interface dynamic model with multiple mechanisms and confirms the high possibility of adequate predictions. In particular, we consider the nucleus that exhibits three-dimensional motion in the crawling cell, which enables a more realistic representation of haptotactic migration. A diffuse interface model that incor-porates the haptotaxis mechanism and interface energies is employed. The semi-implicit Fourier spectral scheme is adopted for efficient evaluation of the simulation model. The simulation results confirm the reliability of the developed model.
Keyword Haptotaxis, Sing crawling cell, Cell migration, Morphology, Interface energy, Diffuse interface model
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