Go to contents

(사)한국바이오칩학회 The Korean BioChip Society





BT+IT+NT융합시대의 리더 : 한국바이오칩학회

학술지 열람

논문 정보 자세히 보기

Info. Vol.4 - No.4 (2010.12.20)
Title Target sequences for microRNAs within the Tff gene cluster
Authors A.A. Shah1 & N. Blin1
Institutions 1Division of Molecular Genetics, Institute of Human Genetics, University of T?ingen, Germany
Correspondence and requests for materials should be addressed to A.A. Shah ( aftabuom@yahoo.com)
Abstract Despite the increasing interest focusing on control of gene activity by microRNAs this abundant class of thousands of regulatory transcripts still requires elucidation of open questions concerning selection of targets and mechanisms of complementarity, multiplicity and cooperativity of microRNAs, to name some immediate issues. In silico microRNA target prediction is often the first line of approaching the complex system and helping in setting search priorities for experimental validation of such mechanisms of gene control. We now used a well studied gene cluster coding for the trefoil peptide family (Tff1, Tff2, Tff3) with all its sequence data and information on factors driving gene expression and a combined computer-based set of target prediction programs to collect microRNAs involved in Tff gene regulation. The sequence preference of specific microRNAs was mapped and their multiplicity and cooperativity were denoted to establish an interactive regulatory profile. This computational venue will subsequently allow enhanced and specific in vitro confirmation of the regulatory networks in cellular systems and possibly later on in transgenic animal models.
Keyword Regulatory molecule, Database, Interaction, Knock out mouse
PDF File
# 2010년도 발행분 부터는 Springer 의 BioChip Journal 페이지에서 전문을 열람하실 수 있습니다.
# 학회회원 로그인 후 [ Springer BioChip Journal 열람하기 ] 버튼을 클릭하시면 새창으로 열립니다.
→ 전체 목록 보기

(사)한국바이오칩학회 (The Korean BioChip Society)
총괄/후원/부스/저널/학술대회
전화 : 070-7767-9855
전자우편 : biochip@biochip.or.kr
등록/초록/학술대회/회원정보/홈페이지
전화 : 070-7767-9867
전자우편 : biochip2@biochip.or.kr
주소 : (우)06130, 서울특별시 강남구 테헤란로7길 22 과학기술회관 신관 804호     대표자 : 심상준, 고유번호 : 206-82-65403
팩스 : 02-921-9856 , 웹사이트 : http://www.biochips.or.kr Copyright © The Korean BioChip Society. All Rights Reserved.