| Info. | Vol.5 - No.1 (2011.03.20) |
|---|---|
| Title | Computational analysis of matrix-degrading enzymes in cancer-cell invasion |
| Authors | Linan Zhang1 & Dongchoul Kim1 |
| Institutions | 1Department of Mechanical Engineering, Sogang University, 1 Shinsoo-dong, Mapo-go, Seoul 122-742, Korea Correspondence and requests for materials should be addressed to D. Kim(dckim@sogang.ac.kr) |
| Abstract | Invasion is one of the hallmarks of cancer cells. Cancer cells secrete enzymes and invade the surrounding matrix. In this paper, a new model primary study on the invasive process of cancer cells is presented. Our three-dimensional haptotaxis model consists of a cancer-cell population, matrix-degrading enzymes (MDEs), and the extracellular matrix (ECM), and it describes two procedures for invasion by cancer cells. In the first step, cancer cells secrete MDEs, and in the next step, the secreted MDEs degrade the ECM. The simulation results thoroughly reveal that the degradation of the ECM is an influential process in cancercell invasion. |
| Keyword | Cancer-cell invasion, Matrix-degrading enzymes, Haptotaxis, Interface energy, Diffuse interface model |
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