| Info. | Vol.5 - No.1 (2011.03.20) |
|---|---|
| Title | Expression profile analysis of human umbilical vein endothelial cells treated with salvianolic acid B from Salvia miltiorrhiza |
| Authors | Hana Yang1, Seung Eun Lee1, Dong Sun Ryu1, Cheung-Seog Park1, Young-Ho Jin2 & Yong Seek Park1 |
| Institutions | 1Department of Microbiology and Medical Science and Engineering
Research Center for Bioreaction to Reactive Oxygen Species 2Department of Physiology, School of Medicine, Kyung Hee University, Seoul, Korea Correspondence and requests for materials should be addressed to Y.S. Park (yongseek@khu.ac.kr) |
| Abstract | Salvianolic acid B (SalB) is a bioactive component in Salvia miltiorrhiza, which is widely used as a traditional oriental medicine for treatment of cardiovascular disorders. As it is known to have cardioprotective effects and anti-inflammatory activities, it has been used for treatment of several vascular diseases. However, the precise mechanism of SalB at the transcriptional level has not so far been determined. In this study, we investigated target genes of SalB in human umbilical vein endothelial cells (HUVECs) by microarray gene expression profiling that allows a global view of gene expression. Among more than 40,000 genes investigated, 140 genes were up-regulat- ed more than 1.7-fold, while 167 genes were down-regulated with altered expression levels of 2-fold. According to their functional characteristics, genes were classified into seven categories. We also showed the distribution of functional groups of target genes in SalB-treated HUVECs. Furthermore, cardiovascular disease-related genes, including PDGS2, TNFSF12, and IFNG, were also altered by SalB. These results suggest that SalB may exert a vasculoprotective effect through transcriptional change of inflammatory genes. In conclusion, our data suggest that these changes in gene expression mediate the anti-inflammatory activities of SalB on vasculopathy. |
| Keyword | Salvia miltiorrhiza, Salvianolic acid, Microar-ray, HUVECs, Endothelial cell, Inflammation |
| PDF File |
 # 2010년도 발행분 부터는 Springer 의 BioChip Journal 페이지에서 전문을 열람하실 수 있습니다.
# 학회회원 로그인 후 [ Springer BioChip Journal 열람하기 ] 버튼을 클릭하시면 새창으로 열립니다. |
