| Info. | Vol.5 - No.3 (2011.09.20) |
|---|---|
| Title | Genome-wide gene expression analysis of Patrinia scabiosaefolia reveals an antibiotic effect |
| Authors | Eun-Kyeong Choi1,??/sup>, Yeo eun Park1,??/sup>, Bo Won Choi1,??/sup>, Ki-Suk Kim1, Hea Jung Yang1, Kwang Seok Ahn1 & Hyeung-Jin Jang1 |
| Institutions | 1College of Oriental Medicine, Institute of Oriental Medicine,
Kyung Hee University, Hoegi-dong, Dongdaemun-gu, Seoul 130-701,Korea ??/sup>These authors contributed equally to this work. Correspondence and requests for materials should be addressed to H.-J. Jang ( hjjang@khu.ac.kr) |
| Abstract | Patrinia scabiosaefolia (PS) clinically had been prescribed in oriental ethnopharmacology, but its exact mechanism is unknown. In this study, we analyzed molecular perspective of antibiotic effects of PS. Escherichia coli O157:H7 was changed in four main mechanisms; (1) Cell wall biosynthesis decreased, (2) DNA transcription consists of folic acid metabolism interruption, (3) Protein synthesis and folding declined, (4) Bacterial cell motility increased. With these results, antibiotic effect was demonstrated at a molecular perspective of PS. Safe and effective drugs for antibiotic resistance will promote with the multi-target herbal medicine. |
| Keyword | Patrinia scabiosaefolia, Herbal medicine, Escherichia coli O157, Antibiosis, Bacterial cell wall,Folic acid |
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