Go to contents

(사)한국바이오칩학회 The Korean BioChip Society

BT+IT+NT융합시대의 리더 : 한국바이오칩학회

학술지 열람

논문 정보 자세히 보기

Info. Vol.5 - No.4 (2011.12.20)
Title Functional synapse formation between compartmentalized cortical neurons cultured inside microfluidic devices
Authors Sanjeev Kumar Mahto1, Hue-sup Song2 & Seog Woo Rhee1
Institutions 1Department of Chemistry, Kongju National University, Kongju 314-701, Korea 2Division of Advanced Materials Engineering, Kongju National University, Cheonan 331-717, Korea
Correspondence and requests for materials should be addressed to S.W. Rhee ( jisanrhee@kongju.ac.kr)
Abstract In this work, the formation of functional synapses between compartmentalized cortical neurons cultured inside three-compartment microfluidic devices in a controlled fashion is described. The proposed device can direct axons in an isolated compartment and, thus, facilitates isolated axons forming functional synapses with dendrites of other neurons in an isolated microenvironment.
This microfluidic approach allows continuous real-time monitoring of neuronal processes and fluorescently tagged biomolecules involved in synapse formation, and provides an easy, simple, cost effective, and efficient method to develop and manipulate synapses in an isolated microenvironment without using surface patterning techniques or electrical stimulation. The results presented here suggest that this microfluidic approach could be used as an alternative method for the formation of functional synapses and their exhaustive examinations.
Keyword Microfluidics, Multicompartments, Cortical neurons, Synapse formation, Real-time monitoring
PDF File
# 2010년도 발행분 부터는 Springer 의 BioChip Journal 페이지에서 전문을 열람하실 수 있습니다.
# 학회회원 로그인 후 [ Springer BioChip Journal 열람하기 ] 버튼을 클릭하시면 새창으로 열립니다.
→ 전체 목록 보기

(사)한국바이오칩학회 (The Korean BioChip Society)
전화 : 070-7767-9855
전자우편 : biochip@biochip.or.kr
전화 : 070-7767-9867
전자우편 : biochip2@biochip.or.kr
주소 : (우)06130, 서울특별시 강남구 테헤란로7길 22 과학기술회관 신관 804호     대표자 : 김민곤, 고유번호 : 206-82-65403
팩스 : 02-921-9856 , 웹사이트 : http://www.biochips.or.kr Copyright © The Korean BioChip Society. All Rights Reserved.