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Info. Vol.5 - No.4 (2011.12.20)
Title ProteoChip-based screening system of novel inhibitors against the interaction of VEGF165 and 棺-Amyloid1-42
Authors Chan-Won Park1,2, Ji Young Bang1,2, Youngjin Choi1,2 & In-Cheol Kang1,2
Institutions 1Innopharmascreen Inc., Asan 336-795, Korea 2Department of Biological Science and BioChip Research Center, Hoseo University, Asan 336-795, Korea
Correspondence and requests for materials should be addressed to I.C. Kang ( ickang@hoseo.edu)
Abstract Vascular endothelial growth factor (VEGF) protects neuronal cells from amyloid-棺(A棺)-induced neurotoxicity in the brain of Alzheimer?셲 disease (AD) patient. However, the accumulation of VEGF in amyloid plaques may induce local VEGF deficiency and promote development of the disease. Here we investigated that A棺1-42 can interact with heparin binding domain (HBD) of VEGF using ProteoChip technology.
The ProteoChip-based A棺-VEGF interaction system has been used for screening of AD inhibitor. An inhibitor of A棺1-42-VEGF165 interaction using a ProteoChip-based screening method showed suppression of A棺1-42-induced neurotoxicity in human neuronal cells.
Keyword VEGF165, 棺-Amyloid, ProteoChipTM, Alzheimer?셲 disease, SH-SY5Y cells
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