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Info. Vol.5 - No.4 (2011.12.20)
Title Hepatic proteome responses against benz[a]anthracene in the rat
Authors Seul-Ki Park1, Yoo-Na Seo1, Suk-Woo Nam2 & Mi-Young Lee1
Institutions 1Department of Medical Biotechnology, SoonChunHyang University, Asan, Chungnam 336-600, Korea 2Department of Pathology, Catholic University, Seoul 137-701, Korea
Correspondence and requests for materials should be addressed to M.Y. Lee ( miyoung@sch.ac.kr)
Abstract Benz[a]anthracene (B[a]A) is one of the most ubiquitous polycyclic aromatic hydrocarbons and environmental pollutants. Mass spectrometrybased proteomics was used to characterize changes in the liver proteome in response to B[a]A exposure. Nine hepatic protein spots were identified that exhibited B[a]A-induced significant expression changes. Of these, six were up-regulated and the rest were downregulated by B[a]A at 10% of its LD50. At 50% of the LD50 of B[a]A, five proteins were up-regulated while the rest were down-regulated. The proteomic results were also consistent with those obtained by western blot. The differential expressions of these proteins may allow them to serve as biomarker candidates for B[a]A toxicity.
Keyword Benz[a]anthracene, Rat, Liver, Proteomics, Differential proteins
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