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Info. Vol.5 - No.4 (2011.12.20)
Title Droplet routing in high-level synthesis of configurable digital microfluidic biochips based on microelectrode dot array architecture
Authors Zhongkai Chen1, Daniel Hsiang-Yung Teng2, Gary Chung-Jhih Wang1 & Shih-Kang Fan3
Institutions 1University of Saskatchewan, Saskatoon, SK. S7N 5A9 Canada 2Electrical and Computer Engineering Department, University of Saskatchewan, Saskatoon, SK. S7N 5A9 Canada 3Materials Science and Engineering Department, National Chiao Tung University, Hsinchu, Taiwan
Correspondence and requests for materials should be addressed to D.H.-Y. Teng ( d.teng@usask.ca)
Abstract Droplet-based digital microfluidic lab-onchips exploiting electrowetting-on-dielectric (EWOD) have been studied over the last decade. With the recent introduction of new highly scalable, reconfigurable and field-programmable microelectrode dot array (MEDA) architecture, there is a compelling need for a new digital microfluidics synthesizer for the new MEDA architecture. Droplet routing is a critical part of the digital microfluidics synthesizer. This paper presents a routing algorithm and the associated performance analysis results. The algorithm is able to route different sizes of reagent and sample droplets simultaneously and also incorporates other characteristics such as diagonal movements and channel -based movements that are specific to the MEDA architecture.
Keyword Digital microfluidics, Microelectrode dot array, Electrowetting-on-dielectric (EWOD), Droplet routing, Biochip synthesis, Lab-on-a-chip (LOC)
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