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Info. Vol.5 - No.4 (2011.12.20)
Title Human lactoferrin upregulates BCL-3 in the K562 erythroleukemia cell
Authors Byungtak Kim1, Ho Gun Chang1,* & Sun Jung Kim1
Institutions 1Department of Life Science, Dongguk University-Seoul, Seoul 100-715, Korea *Present address: Hanmi Pharmaceutical, Gyeonggi-do 445-913, Korea
Correspondence and requests for materials should be addressed to S.J. Kim ( sunjungk@dongguk.edu)
Abstract Lactoferrin (LF) plays pivotal roles in primary defense against microbial infection and other cellular processing including immuno-modulation and growth stimulation of cells. To understand the molecular mechanism of LF action we stably overexpressed LF in the K562 erythroleukemia cells and examined differential gene expression using a cDNA microarray. One of the genes that were highly upregulated in the LF-overexpressing cells was the I觀B family member B cell lymphoma-3 (BCL-3) that is implicated to promote B cell proliferation and chronic lymphocytic leukemia. Northern blot as well as RT-PCR analysis confirmed that BCL-3 was highly induced in LF-transfected cells. Furthermore, by treating the K562 cells with natural LF protein, we observed a significant increase of BCL-3 messages with the peak at 50 關g/mL and 2 h after treatment. These results suggest that LF signals to induce BCL-3 and thereby promotes B cell proliferation and survival.
Keyword B cell, BCL-3, K562, Lactoferrin, Leukemia
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