| Info. | Vol.1 - No.4 (2007.12.20) |
|---|---|
| Title | The Fabrication of Cell Chips for Use as Bio-sensors |
| Authors | Cheol-Heon Yea1, Junhong Min2 & Jeong-Woo Choi1,3 |
| Institutions | 1Department of Chemical & Biomolecular Engineering, Sogang University, Seoul 121-742, Korea 2Department of Bionanotechnology, Gachon Bionano Research Institute, Kyungwon University, Bokjeong-dong, Sujung-gu, Sungnam-si, Gyeonggi-do 461-701, Korea 3Interdisciplinary Program of Integrated Biotechnology, Sogang University, Seoul 121-742, Korea Correspondence and requests for materials should be addressed to J.-W. Choi (jwchoi@sogang.ac.kr) |
| Abstract | The development of biosensors for the detection of chemicals that are used by cells is of great interest to the pharmaceutical and environmental fields because of the potential for biosensors to measure unknown materials that cannot be detected based on their DNA or protein reactions. However, various problems associated with the introduction of cells to micro-devices, such as low reproducibility and sensitivity, must be overcome before biosensors can be used on a commercial scale. Here, we briefly discuss the cultivation of cells within microchips in vitro as well as the biosensor technologies that allow detection of cell properties and subsequent evaluation of specific analytes. |
| Keyword | Cell-based biosensor, Extracellular matrix, Label-free detection, Peptides |
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