| Info. | Vol.8 - No.1 (2014.03.20) |
|---|---|
| Title | Synthesis and characterization of thermoresponsive polymeric nanoparticles |
| Authors | Boram Ku1, Hye In Seo2 & Bong Geun Chung2,* |
| Institutions | 1Department of Bionano Engineering, Hanyang University, Ansan, Korea 2Department of Mechanical Engineering, Sogang University, Seoul, Korea |
| Abstract | We synthesized drug-loaded thermoresponsive poly(N isopropylacrylamide) with acrylic acid (poly(NIPAM-co-AA)) nanoparticles. Dynamic light scattering analysis showed that the size of poly (NIPAM-co-AA) nanoparticles was significantly affected by temperatures, indicating that the sizes were changed from 400 nm at 25C to 100 nm at 37C. 1H nuclear magnetic resonance (NMR) and fourier transform infrared spectroscopy (FT-IR) analysis demonstrated the synthesis of poly(NIPAM-co-AA) nanoparticles, showing that drugs (e.g., doxorubicin, retinoic acid) were conjugated with poly(NIPAM-co-AA) nanoparticles. We also analyzed the cumulative release of drugs in a temporal manner, indicating that doxorubicin was highly released from poly(NIPAM-co-AA) nanoparticles at 48 hours compared to retinoic acid. Therefore, this thermoresponsive drug-loaded poly (NIPAM-co-AA) nanoparticle could be a powerful tool for drug delivery and release applications. |
| Keyword | Nanoparticle, Polymer, Synthesis, Drug delivery, Controlled release |
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