Go to contents

(사)한국바이오칩학회 The Korean BioChip Society

BT+IT+NT융합시대의 리더 : 한국바이오칩학회

학술지 열람

논문 정보 자세히 보기

Info. Vol.8 - No.1 (2014.03.20)
Title Synthesis and characterization of thermoresponsive polymeric nanoparticles
Authors Boram Ku1, Hye In Seo2 & Bong Geun Chung2,*
Institutions 1Department of Bionano Engineering, Hanyang University, Ansan, Korea
2Department of Mechanical Engineering, Sogang University, Seoul, Korea
Abstract We synthesized drug-loaded thermoresponsive poly(N isopropylacrylamide) with acrylic acid (poly(NIPAM-co-AA)) nanoparticles. Dynamic light scattering analysis showed that the size of poly (NIPAM-co-AA) nanoparticles was significantly affected by temperatures, indicating that the sizes were changed from 400 nm at 25􀆆C to 100 nm at 37􀆆C. 1H nuclear magnetic resonance (NMR) and fourier transform infrared spectroscopy (FT-IR) analysis demonstrated the synthesis of poly(NIPAM-co-AA) nanoparticles, showing that drugs (e.g., doxorubicin, retinoic acid) were conjugated with poly(NIPAM-co-AA) nanoparticles. We also analyzed the cumulative release of drugs in a temporal manner, indicating that doxorubicin was highly released from poly(NIPAM-co-AA) nanoparticles at 48 hours compared to retinoic acid. Therefore, this thermoresponsive drug-loaded poly (NIPAM-co-AA) nanoparticle could be a powerful tool for drug delivery and release applications.
Keyword Nanoparticle, Polymer, Synthesis, Drug delivery, Controlled release
PDF File
# 2010년도 발행분 부터는 Springer 의 BioChip Journal 페이지에서 전문을 열람하실 수 있습니다.
# 학회회원 로그인 후 [ Springer BioChip Journal 열람하기 ] 버튼을 클릭하시면 새창으로 열립니다.
→ 전체 목록 보기

(사)한국바이오칩학회 (The Korean BioChip Society)
주소 : (우)06130, 서울특별시 강남구 테헤란로7길 22 과학기술회관 신관 804호     대표자 : 심상준, 고유번호 : 206-82-65403
대표전화 : 070-7767-9855 , 팩스 : 02-921-9856 , 전자우편 : biochip@biochip.or.kr, 웹사이트 : http://www.biochips.or.kr Copyright © The Korean BioChip Society. All Rights Reserved.
Facebook Twitter URL 복사