Go to contents

(사)한국바이오칩학회 The Korean BioChip Society

BT+IT+NT융합시대의 리더 : 한국바이오칩학회

학술지 열람

논문 정보 자세히 보기

Info. Vol.9 - No.2 (2015.06.20)
Title Estimation of Dysregulated Pathway Regions in MPP+Treated Human Neuroblastoma SH-EP Cells with Structural Equation Model
Authors Daniele Pepe1 & Jin Hwan Do2,*
Institutions 1Department of Brain and Behavioural Sciences, Medical and Genomic Statistics Unit, University of Pavia, Pavia, Italy 2Department of Biomolecular and Chemical Engineering, DongYang University, Yeongju 750-711, Korea
Abstract As it is widely accepted that the cellular system is modular and complex diseases are caused by combinations of genetic alternations affecting component of the cellular system, module-centric approaches are promising in the study of Parkinson?셲 disease (PD). To identify module/pathways associated with PD, the gene signaling pathway analysis of 1-methyl-4-phenylpyridinium (MPP+) treated cells of the PD model was performed with their genome-wide gene expression data. Significant pathway perturbation was observed at 14 KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways. To capture differentially regulated regions by MPP+ treatment within these 14 perturbed pathways, the shortest path models linking differentially expressed genes (DEGs) were constructed for each pathway. Each shortest path model was analyzed with structural equation model (SEM) and the significant regulation structure by MPP+ treatment was observed in three shortest pathway models including cell cycle, neurotrophin and phosphatidylinositol signaling pathways. In addition, the connection of neurotrophin and phosphatidylinositol signaling pathway via CALM1 was observed. Our results suggest that the dys-regulation of these three pathways might play important role in neuronal cell death by MPP+ treatment.
Keyword Parkinson disease, Pathway perturbation, MPP+, Shortest path model, Structural equation model
PDF File
# 2010년도 발행분 부터는 Springer 의 BioChip Journal 페이지에서 전문을 열람하실 수 있습니다.
# 학회회원 로그인 후 [ Springer BioChip Journal 열람하기 ] 버튼을 클릭하시면 새창으로 열립니다.
→ 전체 목록 보기

(사)한국바이오칩학회 (The Korean BioChip Society)
전화 : 070-7767-9855
전자우편 : biochip@biochip.or.kr
전화 : 070-7767-9867
전자우편 : biochip2@biochip.or.kr
주소 : (우)06130, 서울특별시 강남구 테헤란로7길 22 과학기술회관 신관 804호     대표자 : 김민곤, 고유번호 : 206-82-65403
팩스 : 02-921-9856 , 웹사이트 : http://www.biochips.or.kr Copyright © The Korean BioChip Society. All Rights Reserved.