Info.
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Vol.10 - No.3 (2016.09.20) |
Title
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Anti-angiogenic Mechanism of IPS-05002, a Novel Antagonist against Integrin 慣5棺1, Determined by ProteoChip-based Antibody Array |
Authors
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Min-A Kim1 & In-Cheol Kang1,2,* |
Institutions
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1Department of Biological Science, College of Natural Science
2BioChip Research Center, Hoseo University, Asan 31499, Republic of
Korea
*Correspondence and requests for materials should be addressed to
I.-C. Kang ( ickang@office.hoseo.ac.kr) |
Abstract
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IPS-05002, a novel antagonist of integrin 慣5棺1, was screened from a phytochemical compound library using ProteoChip-based integrin 慣5棺1-fibronectin interaction assay method. The novel compound inhibited VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation, adhesion, and migration in a dose-dependent manner. It also suppressed tubular network formation. Differential expression profiling
of cell cycle proteins in VEGF-induced HUVECs in the presence of IPS-05002 showed up-regulation of IKB-棺, XRCC4, and down-regulation of Cdc6 compared with HUVECs induced by VEGF alone. In conclusion, these data suggest that IPS-05002 will be a
potent inhibitor for VEGF-mediated angiogenesis. |
Keyword
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Integrin, Angiogenesis, Natural products, Small molecule antagonist, VEGF, Antibody microarray |
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