| Info. | Vol.10 - No.4 (2016.12.20) |
|---|---|
| Title | Microdroplet-based Cell Culture Models and Their Application |
| Authors | Minjeong Jang1, Seungwon Yang1 & Pilnam Kim1,* |
| Institutions | 1Department of Bio and Brain Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea *Correspondence and requests for materials should be addressed to P. Kim (pkim@kaist.ac.kr) |
| Abstract | Microfluidic systems offer precisely controlled experimental conditions for efficient study of mammalian cells, ranged from a single cell to matrixbased three-dimensional (3D) in vitro culture models. Droplet-based microfluidic system is a robust and highly reproducible device enabling encapsulation of a cell or cells within well-confined microenvironment. Recently, such droplet-based cell culture models have drawn much attention due to their unique properties such that conventional culture systems couldn?셳 provide. The encapsulation of cells in specifically designed aqueous phase of a microfluidic system can provide profound understand of cell to cell and cell to extracellular matrix interactions, also can be used to regulate various cell behaviors. A droplet-based cell culture system allows better control over confinement for culturing, maintaining, and analyzing cells, such as high-throughput screening. In this review, we discuss recent researches on microdroplet-based 3D cell culture models, and advanced applications of microfluidic systems. |
| Keyword | Microdroplet, 3D cell culture, Highthroughput, Single cell analysis, Multicellular spheroid, Cell-laden ECM |
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