| Info. | Vol.13 - No.3 (2019.09.20) |
|---|---|
| Title | Multifunctional Nanomaterial-alginate Drug Delivery and Imaging System for Cancer Therapy |
| Authors | Seokyoung Yoon1, Junhyuck Chang2, Nayoung Kwon2, Seokhoon Moon4, Youngmin Park4, Kwon Hoon Han1,* , Byungkwon Lim2,* & Jung Heon Lee1,2,3,* |
| Institutions | 1 SKKU Advanced Institute of Nanotechnology (SAINT), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea 2 School of Advanced Materials Science and Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea 3 Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea 4 Gyeonggi Science High School for the Gifted, Suwon 16297, Republic of Korea † These authors contrilbuted equally. * Correspondence and requests for materials should be addressed to K.H. Han (kwonhoon@skku.edu), B.K. Lim (blim@skku.edu), and J.H. Lee (jhlee7@skku.edu) |
| Abstract | Although chemotherapy is mostly performed by direct injection of the chemotherapeutic agents systemically, this approach can cause undesirable side effects in normal tissues and lacks targeting efficiency. In this study, we have developed a micron-sized, bead-type multifunctional anticancer-drug carrier that can be injected in the vicinity of a lesion using a syringe. The multifunctional anticancer-drug carrier bead was fabricated by incorporating functional nanomaterials, such as near-infrared (NIR)-responsive gold nanorod (GNR) and superparamagnetic iron oxide nanoparticles (IONP) that work as a magnetic resonance imaging (MRI) contrast agent, into an alginate hydrogel bead. The carrier bead containing GNR and IONP was spherical, with an average size of 362.2 ± 22.7 μm. These multifunctional anticancer-drug carrier beads could successfully release doxorubicin (Dox) into the external environment upon irradiation with an NIR laser. The laser responsive on-demand release profile demonstrated well-controlled and sustained release of Dox, and the effectiveness of this drug delivery system can be confirmed in vitro by the 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Additionally, the control experiments evidenced that the thermal effect of GNR was insignificant and the cytotoxic action of Dox was expressed only after irradiation with the NIR laser. The multifunctional anticancer-drug carrier beads can be precisely monitored with the MRI T2 imaging mode. |
| Keyword | Microbead, On-demand drug delivery, Functional nanomaterials, Near infrared (NIR) |
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