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(사)한국바이오칩학회 The Korean BioChip Society

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Info. Vol.13 - No.4 (2019.12.20)
Title Hydrogel-integrated Microfluidic Systems for Advanced Stem Cell Engineering
Authors Soohwan An, Seung Yeop Han & Seung-Woo Cho*
Institutions Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea
*Correspondence and requests for materials should be addressed to S.-W. Cho (seungwoocho@yonsei.ac.kr)
Abstract Previous culture techniques are often ineffective for providing appropriate conditions to cells grown in vitro for efficient growth and maturation. However, the advent of microfluidic chips allows us to manipulate various factors from co-culturing cells to inducing shear stress and biochemical gradient. The above have all been effectively applied to stem cell engineering, allowing dynamic interactions with other cells and, as a result, acquisition of a more mature state. The introduction of both synthetic and natural hydrogels into the chip provides more precise in vivo-like biophysical and biochemical cues to cells, enabling better recapitulation of the in vivo-like physiological behaviors and further maturation of stem cells even to the scale of organoids. This review addresses fundamental roles of microfluidic chips and hydrogels and how hydrogel-integrated chip systems provide breakthroughs in advanced stem cell engineering.
Keyword Hydrogel, Microenvironment, Microfluidics, Organoid, Stem cell
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