Info.
|
Vol.14 - No.1 (2020.03.20) |
Title
|
Real-time Monitoring of Biomarkers: Current Status and Future Perspectives |
Authors
|
Se-Hwan Paek* |
Institutions
|
Department of Biotechnology and Bioinformatics, Korea University, 2511 Sejong-ro, Sejong 30019, Republic of Korea
*Correspondence and requests for materials should be addressed to S.H. Paek (shpaek@korea.ac.kr)
|
Abstract
|
Real-time monitoring is a technique that can be accomplished in the future by continuous or high-frequency analyses of biomarkers indicating disorders (e.g., acute myocardial infarction) in an unattended manner, which eventually will occur in wearable or implantable biosensor formats (refer to Figure 1)1. This technique can enable early diagnosis and prognosis for target diseases, and even provide information related to the disease in progress and therapeutic effect in personalized medicine. The biochemical signs related to a disease will be combined with real-time physical signals such as cardiac impulse and pulsation, significantly increasing diagnostic accuracy2. A great number of disease-related biomarkers have been clinically validated, and various types of analytes from simple molecules, such as ions and metabolites, to large, complex markers, such as proteins and cells, are available. To achieve unattended care through real-time monitoring, unmet technical demands remained are as follows: 1) (semi-)continuous drawings of venous blood without pains and infection, 2) (semi-)continuous separation of blood cells, 3) recyclable immunosorbent, 4) miniaturized, possibly, label-free sensor system, 5) in situ baseline correction algorithm, and 6) secure data transmission. |
Keyword
|
Real-time monitoring, Biomarkers, Liquid biopsy, Unattended healthcare, Unmet needs |
PDF File
|
# 2010년도 발행분 부터는 Springer 의 BioChip Journal 페이지에서 전문을 열람하실 수 있습니다.
# 학회회원 로그인 후 [ Springer BioChip Journal 열람하기 ] 버튼을 클릭하시면 새창으로 열립니다.
|