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Info. Vol.14 - No.1 (2020.03.20)
Title Real-time Monitoring of Biomarkers: Current Status and Future Perspectives
Authors Se-Hwan Paek*
Institutions Department of Biotechnology and Bioinformatics, Korea University, 2511 Sejong-ro, Sejong 30019, Republic of Korea
*Correspondence and requests for materials should be addressed to S.H. Paek (shpaek@korea.ac.kr)
Abstract Real-time monitoring is a technique that can be accomplished in the future by continuous or high-frequency analyses of biomarkers indicating disorders (e.g., acute myocardial infarction) in an unattended manner, which eventually will occur in wearable or implantable biosensor formats (refer to Figure 1)1. This technique can enable early diagnosis and prognosis for target diseases, and even provide information related to the disease in progress and therapeutic effect in personalized medicine. The biochemical signs related to a disease will be combined with real-time physical signals such as cardiac impulse and pulsation, significantly increasing diagnostic accuracy2. A great number of disease-related biomarkers have been clinically validated, and various types of analytes from simple molecules, such as ions and metabolites, to large, complex markers, such as proteins and cells, are available. To achieve unattended care through real-time monitoring, unmet technical demands remained are as follows: 1) (semi-)continuous drawings of venous blood without pains and infection, 2) (semi-)continuous separation of blood cells, 3) recyclable immunosorbent, 4) miniaturized, possibly, label-free sensor system, 5) in situ baseline correction algorithm, and 6) secure data transmission.
Keyword Real-time monitoring, Biomarkers, Liquid biopsy, Unattended healthcare, Unmet needs
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(사)한국바이오칩학회 (The Korean BioChip Society)
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