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Info. Vol.14 - No.1 (2020.03.20)
Title Real-time Monitoring of Biomarkers in Serum for Early Diagnosis of Target Disease
Authors Dong-Hyung Kim1,3,†, Sung-Ho Paek2,†, Da-Yeon Choi2, Min-Kyung Lee1,2, Ji-Na Park4, Hyun-Mo Cho3 & Se-Hwan Paek1,2,5,*
Institutions 1Department of Bio-Microsystem Technology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea
2SOL Bio Corporation, 635 R&D Center, Korea University, Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea
3Korea Research Institute of Standards and Science, P.O. Box 102, Yuseong, Daejon 34113, Republic of Korea
4Abbott Diagnostics Korea Inc.,65 Borahagal-ro, Yongin 17099, Republic of Korea
5Department of Biotechnology and Bioinformatics, Korea University, Sejong-ro 2511, Sejong 30019, Republic of Korea
These authors contrilbuted equally.
*Correspondence and requests for materials should be addressed to S.H. Paek (shpaek@korea.ac.kr)
Abstract Real-time monitoring of biomarkers has important applications in immediately determining, for example, disease progress or therapeutic effects to clinical decisions in the fields of diagnosis, prognosis and therapy. However, technologies developed in this area require frequent sample drawings, unattended analysis in situ, secure online monitoring, and, above all, patient’s safety, so from this point of view are still in their infancy. Current research activity in the area has been restricted to the extent of monitoring physical signals while glucose is the only biomarker generally monitored in real-time. To realize the future of unattended analysis, our research group has investigated various immuno-analytical concepts that enable, in particular, repetitive measurements of target biomarkers in a continuous or semi-continuous manner. The key actors in these achievements were monoclonal antibodies with unique characteristics, raised in our group, that potentially allow for real- time monitoring of target disease markers from tiny ionic molecules to complex proteins. Furthermore, we have investigated surrogate elements (e.g. receptors and cytokines) that translate cellular response to measurable signals, enabling us to determine the functional properties of analytes. In this review, continuous and semi-continuous monitoring techniques of different markers for acute myocardial infarction are presented.
Keyword Unattended monitoring, Immunosorbent recycling, Rapidly reversible antibody, Conformation change-sensitive antibody, Acute myocardial infarction, Label-free sensor
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