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(사)한국바이오칩학회 The Korean BioChip Society

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Info. Vol.14 - No.1 (2020.03.20)
Title Advancements in DNA-assisted Immunosensors
Authors Juyoung Kang & Min-Gon Kim*
Institutions Department of Chemistry, School of Physics and Chemistry, Gwangju Institute of Science and Technology (GIST), 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea
*Correspondence and requests for materials should be addressed to M.-G. Kim (mkim@gist.ac.kr)
Abstract Several types of biosensors have been developed to detect a wide variety of human diseases. Immunosensors are classified as the most representative of all biosensors. They are based on antibodies that selectively recognize specific analytes and have high specificity and sensitivity. However, there are limitations to the types of substances that can be detected, and it is sometimes difficult to achieve sufficient sensitivity without additional amplification steps. To overcome these problems, novel immunosensors are being developed that combine DNA-based high signal amplification systems. These technologies ameliorate the low sensitivity of existing immunosensors by using DNA probes that can bind directly to targets as bioreceptors or act as signal amplifiers. In this review, we will discuss immunodetection methods that use DNA-based technologies on laboratory-scale and advanced point-of-care testing (POCT) that employ these technologies for high performance analyses.
Keyword Immunosensor, DNA, Bioreceptors, Signal amplification, Point-of-care testing (POCT), Sensitivity
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