| Info. | Vol.14 - No.1 (2020.03.20) |
|---|---|
| Title | Nanoelectrokinetic Selective Preconcentration Based on Ion Concentration Polarization |
| Authors | Jihye Choi1,†, Seongho Baek1,†, Hee Chan Kim2, Jong-Hee Chae3, Youngil Koh4, Sang Woo Seo5, Hyomin Lee6,* & Sung Jae Kim1,7,8,* |
| Institutions | 1Department of Electrical and Computer Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea 2Department of Biomedical Engineering, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea 3Department of Pediatrics, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea 4Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu,Seoul 03080, Republic of Korea 5School of Chemical and Biological Engineering, Institute of Chemical Process, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea 6Department of Chemical and Biological Engineering, Jeju National University, 102 Jejudaehak-ro, Jeju-si, Jeju, 63243, Republic of Korea 7Nano Systems Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. 8Inter-university Semiconductor Research Center, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea †These authors contrilbuted equally. *Correspondence and requests for materials should be addressed to S.J. Kim (gates@snu.ac.kr) and H. Lee (fluid@jejunu.ac.kr) |
| Abstract | Nanoscale electrokinetic phenomenon called ion concentration polarization (ICP) has opened a new era in bio- and chemical-analysis platform due to its high efficiency and easy sample handling. In this review, the most recent advancements of selective preconcentration process using ICP were introduced. The flux balances of charged analytes were theoretically analyzed so that the behavior and the shape of preconcentrated plug were categorized into stacking/propagating and dumbbell/plug, respectively. The experimental demonstrations of these features were also given to verify the modeling. Furthermore, promising applications based on the analysis were described in this review. Lastly, future research direction would be suggested by elucidating pros and cons of ICP process. |
| Keyword | Ion concentration polarization, Nanoelectrokinetics, Selective preconcentration, Biomolecules, Perm-selective ion transportation, Critical mobility, Driftless preconcentration |
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