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Info. Vol.14 - No.1 (2020.03.20)
Title Surface Sensitive Analysis Device using Model Membrane and Challenges for Biosensor-chip
Authors Ji Min Baek1,2 & Yong-Sang Ryu1,*
Institutions 1Sensor System Research Center, Korea Institute of Science and Technology, 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea
2Department of Chemical & Biological Engineering, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea
*Correspondence and requests for materials should be addressed to Y.-S. Ryu (ysryu82@kist.re.kr)
Abstract Lipid membranes and their applications in analytical biochip devices represent a great tool for the study of membrane dynamics and the related biological phenomena. Lipid-membrane-assisted surfacesensitive sensors have employed to provide biological information as they improve molecular survivability as well as rule out incorrect signals arising from unwanted nonspecific binding between target molecules with sensor surfaces. To enhance the accuracy of the signal as well as the sensitivity of biochip sensors, a variety of strategies have been employed. Here, we introduce various types of in vitro model membrane platforms/techniques and discuss current challenges in the lipid-membrane-assisted surface-sensitive analytical sensors application.
Keyword Lipid membrane, Supported lipid bilayer, sensor, Lipid raft, Biochip
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(사)한국바이오칩학회 (The Korean BioChip Society)
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