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Info. Vol.14 - No.4 (2020.12.20)
Title Locally Controlled Diffusive Release of Bone Morphogenetic Protein-2 Using Micropatterned Gelatin Methacrylate Hydrogel Carriers
Authors Myong-Hee Yi1, Ji-Eun Lee2, Chang-Beom Kim3, Keun-Woo Lee1,* & Kwang-Ho Lee4,*
Institutions "1Department of Prosthodontics, College of Dentistry, Yonsei University, Seoul 03722, Republic of Korea
2Graduate Program of Advanced Functional Materials and Devices Development, Kangwon National University, Chuncheon, 24341, Republic of Korea
3Intelligent Robot Research Team, Electronics and Telecommunications Research Institute, Daejeon 34129, Republic of Korea
4Division of Mechanical & Biomedical, Mechatronics and Materials Science and Engineering, Chuncheon, Kangwon National University, 24341, Republic of Korea
*Correspondence and requests for materials should be addressed to K-W. Lee (kwlee@yuhs.ac) and K-H. Lee (khmhlee@kangwon.ac.kr) "
Abstract In this work, a novel and simple bone morphogenetic protein (BMP)-2 carrier is developed, which enables localized and controlled release of BMP-2 and facilitates bone regeneration. BMP-2 is localized in the gelatin methacrylate (GelMA) micropatterns on hydrophilic semi-permeable membrane (SNM), and its controlled release is regulated by the concentration of GelMA hydrogel and BMP-2. The controlled release of BMP-2 is verified using computational analysis and quantified using fluorescein isothiocyanate-bovine serum albumin (FITC-BSA) diffusion model. The osteogenic differentiation of osteosarcoma MG-63 cells is manipulated by localized and controlled BMP-2 release. The calcium deposits are significantly higher and the actin skeletal networks are denser in MG-63 cells cultured in the BMP-2- immobilized GelMA micropattern than in the absence of BMP-2. The proposed BMP-2 carrier is expected to not only act as a barrier membrane that can prevent invasion of connective tissue during bone regeneration, but also as a carrier capable of localizing and controlling the release of BMP-2 due to GelMA micropatterning on SNM. This approach can be extensively applied to tissue engineering, including the localization and encapsulation of cells or drugs.
Keyword Bone generation, Gelatin-methacrylate, Localized release, Controlled release, Bone morphogenetic protein-2
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