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Info. Vol.2 - No.4 (2008.12.20)
Title Label-free Detection of Antibody-Antigen Interaction by Si Nanowire MOSFET
Authors Nam Kyung Hong1,2, Hyung Gyoo Lee2, Min So Lee3 & In-Cheol Kang4
Institutions 1Silicon Works, Co. Ltd
2School of Electrical and Computer Engineering, Chungbuk National University
3Seed Bio Chips, Co. Ltd
4 BioChip Research Center and Department of Biological Science, Hoseo University
Correspondence and requests for materials should be addressed to H.G. Lee (hglee@chungbuk.ac.kr), I.C. Kang (ickang@hoseo.edu)
Abstract We have fabricated Si nanowire transistors for protein detection using an SOI wafer and ultra-thin hafnium oxides as a gate dielectric. When a self-assembled monolayer is formed using a ProLinker on the gate dielectrics, the conductance of a transistor increases, and further attachment of hIgG protein on the surface does not noticeably change the conductance. By contrast, additional immobilization of antihIgG protein over the hIgG has reduced the conductance by antibody-antigen interaction and has exhibited the largest conductance change. These results confirm that this device has recognized a specific protein reaction through direct electrical detection.
Keyword Si-NW MOSFET, Label-free detection, Pro Linker, Nanobiosensor, Hafnium oxide
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