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(사)한국바이오칩학회 The Korean BioChip Society

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Info. Vol.2 - No.4 (2008.12.20)
Title Terahertz Time Domain Spectroscopy of Crystalline 慣-Lactose Monohydrate
Authors Euna Jung1, Jeonghoi Kim1, Younho Han1, Kiwon Moon1, Meehyun Lim1 & Haewook Han1
Institutions 1National Research Laboratory for Nano-THz Photonics, Department of Electrical and Computer Engineering, Pohang University of Science and Technology, Pohang 790-784, Korea
Correspondence and requests for materials should be addressed to H. Han (hhan@postech.ac.kr)
Abstract Fundamental biological processes require both small- and large-scale structural changes within molecules, including low frequency collective vibrational motions. Many theoretical calculations have predicted that the collective vibrational motion can be characterized as the large-scale intermolecular motions in the terahertz (THz) frequency range. A new measurement technique based on THz time domain spectroscopy (TDS) can probe directly the collective vibrational motions of biomolecules which involve structural changes and specific biological functions. We report the THz TDS of solid state 慣-lactose monohydrate to characterize the collective vibrational motions. Our measurements show that the THz transmission spectrum of 慣-lactose monohydrate has strong absorption peaks centered at 0.531, 1.195, 1.38, and 1.81 THz, which result from intermolecular interactions.
Keyword Terahertz time domain spectroscopy, Low frequency vibrational modes, 慣-Lactose monohydrate, Intermolecular interactions, Biosensing
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