| Info. | Vol.3 - No.4 (2009.12.20) |
|---|---|
| Title | Fabrication of Microneedle Using Laser Written PDMS Mold for Molecule Transport into Plant Skin |
| Authors | Bong-Jin Kim1, Hyung-Jun Kim1, Sung Mok Jung1, Jwa-Kyung Sung2& Hyun Ho Lee1 |
| Institutions | 1Department of Chemical Engineering, Myongji University, Gyeonggi, Yongin 449-728, Korea 2Department of Agricultural Environment, National Academy of Agricultural Science, Rural Development Administration, Gyeonggi, Suwon 441-707, Korea Correspondence and requests for materials should be addressed to H.H. Lee (hyunho@mju.ac.kr) |
| Abstract | A laser writer was simply adopted to fabricate a PDMS microneedle mold having tapered cone tips for molecule or drug delivery. The advantage of the laser patterned PDMS mold was that it lacks of fabrication steps of a precedent master template, which requires many micro-fabrication steps. The laser fabrication had great efficiency with repeatability in manufacturing and simplicity in its process. By controlling laser power and writing speed, needle-tips having as small radius as 5 關m at vertex curvature could be fabricated. The length of the needle could range from 270 關m to 1500 關m. The biocompatible and biodegradable polymers of carboxy methylcellulose (CMC) and agarose were applied on the laser fabricated PDMS molds to cast microneedle replicas and tested their characteristics for a pore forming agent to plant skin. The results demonstrated the feasibility of successful application to a cost-effective manufacturing of microneedle and the availability of controlled transport of molecules, such as nutritions, for plant skin. |
| Keyword | Microneedle, Plant, PDMS (Polydimethylsilonane), CMC (Carboxymethyl Cellulose), Laser writer |
| PDF File |
|
