| Info. | Vol.4 - No.3 (2010.09.20) |
|---|---|
| Title | Development of three-dimensional haptotaxis model for single crawling cell |
| Authors | Jihwan Song1 & Dongchoul Kim1 |
| Institutions | 1Department of Mechanical Engineering, Sogang University,
1 Sinsu-dong, Mapo-gu, Seoul, Korea Correspondence and requests for materials should be addressed to D. Kim (dckim@sogang.ac.kr) |
| Abstract | This paper proposes a three-dimensional diffuse interface dynamic model with multiple mechanisms and confirms the high possibility of adequate predictions. In particular, we consider the nucleus that exhibits three-dimensional motion in the crawling cell, which enables a more realistic representation of haptotactic migration. A diffuse interface model that incor-porates the haptotaxis mechanism and interface energies is employed. The semi-implicit Fourier spectral scheme is adopted for efficient evaluation of the simulation model. The simulation results confirm the reliability of the developed model. |
| Keyword | Haptotaxis, Sing crawling cell, Cell migration, Morphology, Interface energy, Diffuse interface model |
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