| Info. | Vol.6 - No.4 (2012.12.20) |
|---|---|
| Title | Water-stable single-walled carbon nanotubes coated by pyrenyl polyethylene glycol for fluorescence imaging and photothermal therapy |
| Authors | Kuewhan Jang1, Kilho Eom2, Gyudo Lee2, Jae-Hee Han3, Seungjoo Haam4, Jaemoon Yang5, Eunseon Kim6, Woo-Jae Kim6 & Taeyun Kwon2 |
| Institutions | 1Department of Mechanical Engineering, Korea University,
Seoul 136-701, Korea 2Department of Biomedical Engineering, Yonsei University, Wonju 220-710, Korea 3Department of Energy IT, Gachon University, Seongnam, Gyeonggi-do 461-701, Korea 4Department of Chemical Engineering and Biomolecular Engineering, Yonsei University, Seoul 120-751, Korea 5Department of Radiology, College of Medicine, Yonsei University, Seoul 120-752, Korea 6Department of Chemical and Environmental Engineering, Gachon University, Seongnam, Gyeonggi-do 461-701, Korea Correspondence and requests for materials should be addressed to T. Kwon ( tkwon@yonsei.ac.kr) and W.-J. Kim ( wjkim@gachon.ac.kr) |
| Abstract | Nanomaterials have recently received significant attention as photothermal agents and fluorescence contrast agents for molecular therapeutics due to their unique optical properties (e.g. light absorption). In particular, single-walled carbon nanotubes (SWNTs) have been recently utilized as photothermal agents (for photothermal therapy) because of the solubility of SWNTs as well as their light absorbing capability at the near-infrared region. In this work, we have developed the SWNT-based photothermal agents using pyrene-based PEGylation of SWNTs. FT-IR and/or H-NMR spectroscopies have validated the PEGylation of SWNTs, and it is shown that water-soluble SWNTs are able to generate heat under near-infrared (NIR) irradiation of 5W/cm2. Moreover, it is found that our pyrene-based PEGylated SWNTs exhibit the fluorescence characteristic under the excitation wavelength of 340 nm. Our study sheds light on the pyrenyl PEGylated SWNTs as photothermal agents and/or fluorescence contrast agents for the future applications in molecular therapeutics. |
| Keyword | Single-walled carbon nanotube, Pyrenyl group, Polyethylene glycol, Fluorescence imaging agent, Photothermal therapy |
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