| Info. | Vol.7 - No.4 (2013.12.20) |
|---|---|
| Title | Innate immune response gene expression profiles in specific pathogen-free chickens infected with avian influenza virus subtype H9N2 |
| Authors | Dong-Hun Lee1, Seong-Su Yuk1, Jae-Keun Park1, Jung-Hoon Kwon1, Tseren-Ochir Erdene-Ochir1, Jin-Yong Noh1, So Yeon Yu2,3, Seung Yong Hwang2,3,Sang-Won Lee1 & Chang-Seon Song1 |
| Institutions | 1Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul, Korea 2Department of Biochemistry, Hanyang University, Sangrok-gu, Ansan, Gyeonggi-do 426-791, Korea 3GenoCheck Co. Ltd., Guro-gu, Seoul 152-766, Korea |
| Abstract | In poultry species, H9N2 low pathogenic avian influenza (LPAI) virus infections frequently lead to low to moderate mortality rates and morbidity characterized by depression, respiratory disease symptoms, and decreases in egg production. Since current knowledge on the avian immune response to H9N2 infection is limited, we used microarray analysis to examine global changes in immune-related gene expression induced by H9N2 LPAI infection in specific pathogenfree chickens. The expression profiles of approximately 800 genes, including those that influence cell differentiation, transcription, transport, immune responses, and signal transduction, were altered by H9N2 infection. A complete chicken genome microarray analysis identified a strong innate antiviral host response after infection in spleens. In particular, a significant number of immune response genes, including interferon genes and related immune response genes, were upregulated following H9N2 infection. The increased transcription of 2??5??oligoadenylate synthetase and myxovirus resistance genes was confirmed by real-time RT-PCR. These results suggest that the host response generated against H9N2 infection may contribute to protective effects by manipulating innate immune responses. |
| Keyword | Avian influenza virus, H9N2, Microarray, Innate immunity, Interferon |
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