| Info. | Vol.8 - No.4 (2014.12.20) |
|---|---|
| Title | Nanoplasmonic Biopatch for in vivo Surface Enhanced Raman Spectroscopy |
| Authors | Sang-Gil Park1, Myeong-Su Ahn1, Young-Jae Oh1, Minseok Kang1, Yong Jeong1 & Ki-Hun Jeong1,* |
| Institutions | 1Department of Bio and Brain Engineering and KAIST Institute for Optical Science and Technology, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Korea |
| Abstract | Surfaced enhanced Raman scattering (SERS) has been extensively exploited for label-free and non-destructive biochemical detections. Recently diverse SERS substrates have been reported to improve sensitivity of SERS. However, the current platforms still have technical limitation for in vivo applications. Here, we report a nanoplasmonic biopatch of plasmonic nanoparticles physically embedded in highly biocompatible and Raman inactive agarose hydrogel. Molecular diffusion of small molecules such as neurotrans mitter through nanoplasmonic biopatch was quantitatively visualized without labeling by using real-time microscopic SERS. In particular, the nano/micro porous structures within agarose hydrogel allow the SERS detection of macromolecules such as amyloid fibrils. This soft SERS platform opens up new opportunities for in vivo SERS applications. |
| Keyword | Plasmonic nanoparticles, In vivo SERS, Neurotransmitter, Agarose gel, Beta-amyloid |
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