| Info. | Vol.9 - No.3 (2015.09.20) |
|---|---|
| Title | Intravitreal Injection of Anti-Vascular Endothelial Growth Factor (anti-VEGF) Antibody via Tower Microneedle |
| Authors | Chang Yeol Lee1, Yonghao Ma1, Yong Sung You2, Hyoung Eun Kim2, Young Dook Byeon3& Hyungil Jung1,* |
| Institutions | 1Department of Biotechnology, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea 2NUNE Eye Hospital, Nune Bldg. 907-16, Daechi-dong Gangnam-gu, Seoul 135-280, Korea 3INCYTO R&D Center, #460, Chonhung-ri Songgo-eup Seobuk-gu, Cheonan-si, Chungcheongnam-do 331-836, Korea |
| Abstract | Tower Microneedle was developed with minimal ocular tissue damages even reflux, while no study was reported with intravitreal injection of ophthalmic drug via Tower Microneedle into the eye. Intravitreal injection of anti-vascular endothelial growth factor antibodies via the Tower Microneedle or a 30-G hypodermic needle was performed 1 week after argon laser irradiation into the retina of the mouse models. Less bleb formation was occurred with Tower Microneedle than 30-G hypodermic needle, while both needles led to comparable degrees of anti-angiogenesis in the retina after intravitreal injection of anti-vascular endothelial growth factor antibodies over 100 ng/關L concentration. Conclusively, the Tower Microneedle can deliver anti-vascular endothelial growth factor antibody into the posterior segment of the eye with minimal bleb formation after intravitreal injection. |
| Keyword | Intravitreal injection, Tower Microneedle, Age-related macular degeneration, anti-VEGF, Choroidal neovascularization |
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