| Info. | Vol.9 - No.3 (2015.09.20) |
|---|---|
| Title | Integrative Analysis of miRNA and mRNA Profiles in Response to Myricetin in Human Endothelial Cells |
| Authors | Seung Eun Lee1, Gun Woo Son1, Hye Rim Park1, Young-Ho Jin2, Cheung-Seog Park1& Yong Seek Park1,* |
| Institutions | 1Department of Microbiology, School of Medicine, Kyung Hee University, Seoul 130-701, Korea 2Department of Physiology, School of Medicine, Kyung Hee University, Seoul 130-701, Korea |
| Abstract | MicroRNAs (miRNAs) are associated with a diverse range of biological processes, human diseases, and metabolic disorders. Myricetin, which is the most abundant polyphenol class in the human diet, has antioxidative, antiapoptotic, and anti-inflammatory properties. The present study aimed to evaluate whether myricetin modulates miRNA expression. Using microarray analysis, we investigated miRNA expression in human endothelial cells treated with 25 關M and 100 關M of myricetin for 24 hours, and found that 101 and 191 miRNAs, respectively, were differential expressed by at least 1.5-fold. Based on several bioinformatic systems, we also identified signatures of the potential biological processes and signaling pathways that are influenced by dysregulated miRNAs. Therefore, integrating specific patterns of miRNA and mRNA levels may suggest a new mechanism of action of myricetin. |
| Keyword | Endothelial cells, Myricetin, Polyphenol, miRNA, Vascular diseases |
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