| Info. | Vol.11 - No.1 (2017.03.20) |
|---|---|
| Title | Glucose Detection Using 4-mercaptophenyl Boronic Acid-incorporated Silver Nanoparticles-embedded Silica-coated Graphene Oxide as a SERS Substrate |
| Authors | Xuan-Hung Pham1, Seongbo Shim1, Tae-Han Kim1, Eunil Hahm1, Hyung-Mo Kim 1, Won-Yeop Rho1, Dae Hong Jeong2, Yoon-Sik Lee3 & Bong-Hyun Jun1,* |
| Institutions | 1Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea 2Department of Chemistry Education, Seoul National University, Seoul 08826, Republic of Korea 3School of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Republic of Korea *Correspondence and requests for materials should be addressed to B.-H. Jun (bjun@konkuk.ac.kr) |
| Abstract | In this work, 4-mercaptophenyl boronic acid (4-MPBA) was self-assembled on the surface of silver nanoparticle-embedded silica-coated graphene oxide (GO@SiO2@Ag NPs@MPBA) to detect glucose by surface enhanced Raman scattering (SERS). The SERS intensity of 4-MPBA on the GO@SiO2@Ag NPs was 2.2-fold greater than that of GO@Ag NPs. Moreover, silica-coated GO exhibited lower background signals compared to GO. The SERS intensity of GO@ SiO2@Ag NPs@MPBA peaked at 1 mM 4-MPBA. pH-dependent behavior of 4-MPBA on the GO@SiO2 @Ag NPs was investigated; the highest SERS signal intensity was detected at pH 3. The binding of glucose to 4-MPBA-incorporated GO@SiO2@Ag NPs increased the SERS signals at both 1,072 and 1,588 cm-1. The linear range was estimated from 2 to 20 mM glucose. These results provide insight into detection of glucose and the development of SERS-based biosensors using graphene oxide. |
| Keyword | Glucose detection, Graphene oxide, Silica coating, SERS, Signal enhancement |
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