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Info.
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Vol.2 - No.1 (2008.03.20) |
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Title
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Effective Methods to Improve the Biocompatibility of Poly
(dimethylsiloxane) |
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Authors
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Joong Yull Park1,Chang Mo Hwang1,2,& Sang-Hoon Lee1 |
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Institutions
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1Department of Biomedical Engineering, College of Medicine, Korea University, Anam-dong, Seongbuk-gu, Seoul 136-705, Republic of Korea
2Korea Artificial Organ Center, Korea University, Anam-dong, Seongbuk-gu, Seoul 136-705, Republic of Korea
??/sup>These authors contributed equally to this work. Correspondence and requests for materials should be addressed to S.H. Lee (dbiomed@korea.ac.kr) |
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Abstract
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Poly (dimethylsiloxane) (PDMS) has become one of the popular materials in the field of bio-related microfluidic systems, and has been used for various biological assays. While the material is known to be biocompatible in general, it also has been reported that the attachment and survival rate of cells are limited on a PDMS substrate. In this paper, a simple and relevant method to improve heiocompatibilityof PDMS is proposed; the effects of various treatments using ethanol, water, and boiling-water were evaluated. The results show that the boiling-water treatment is the most appropriate, time saving, and simple method to improve the biocompatibility of PDMS.
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Keyword
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Biocompatibility, PDMS, Microfluidic chip, Fibroblast |
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PDF File
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