| Info. | Vol.11 - No.3 (2017.09.20) |
|---|---|
| Title | Gold Nanoislands Chip for Laser Desorption/Ionization (LDI) Mass Spectrometry |
| Authors | Joo-Yoon Noh1, Jo-Il Kim1, Young Wook Chang1, Jong-Min Park1, Hyun-Woo Song1, Min-Jung Kang2 & Jae-Chul Pyun1,* |
| Institutions | 1Department of Materials Science and Engineering, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 03722, Republic of Korea 2Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea *Correspondence and requests for materials should be addressed to J.-C. Pyun (jcpyun@yonsei.ac.kr) |
| Abstract | Gold nanoislands chip were developed as a solid matrix for the analysis of small molecules using laser desorption/ionization time-of-flight (LDIToF) mass spectrometry substituting the organic matrices which usually produce strong noise at low massto- charge ratio range (m/z<500). Gold nanoislands were simply prepared by (1) deposition of gold layer on highly P-doped silicon substrate followed by (2) heating. Physical properties of the gold nanoislands were analyzed by scanning electron microscope (SEM), atomic force microscopy (AFM) analysis to characterize the morphology, diameter, thickness, and surface density of the nanoislands which were comparatively analyzed in conjunction with LDI-ToF mass spectrometry. In this work, optimal size of the nanoislands were selected for LDI-ToF mass spectrometry, and gold nanoislands chip were applied to the quantitative and simultaneous detection of small analytes (amino acids) with various chemical and physical properties (polar, nonpolar, acidic, and basic). |
| Keyword | Gold nanoislands, Solid matrix, LDI-ToF mass spectrometry, Amino acids, Localized surface plasmon resonance |
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