| Info. | Vol.11 - No.4 (2017.12.20) |
|---|---|
| Title | Colorimetric Schirmer Strip for Tear Glucose Detection |
| Authors | Byoung-Hoon Kang1, Moonseong Park1 & Ki-Hun Jeong1,* |
| Institutions | 1Department of Bio and Brain Engineering and KAIST Institute for Optical Science and Technology, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea *Correspondence and requests for materials should be addressed to K.H. Jeong (kjeong@kaist.ac.kr) |
| Abstract | Human tears have attracted attention with easy-accessible indicators of healthcare monitoring. Recently self-monitoring of tear glucose in place of blood glucose has been developed with microfluidic paper-based analysis for a non-invasive diagnosis of diabetes. However, most previous works still have many limitations in unstable sample collection, low sensitivity, and insufficient sample volume. Here, we report a colorimetric Schirmer strip with preconcentration for tear glucose detection. A wax barrier on a paper strip enables tear collection of a fixed quantity as well as biocompatible incorporation of tear collection and detection by preventing flow reversal of reagents. Additional solvent was injected on a sampling site after tear collection, which accumulates the dispersed glucose into active site by capillary-driven flow for signal amplification. Glucose concentration was quantitatively detected at 0.1-2 mM by using a simple colorimetric method without any further image processing. The color changes in glucose concentration were clearly distinguishable between normal and diabetic patient-level. The colorimetric paper strip allows straightforward sensing platform for noninvasive diagnosis of diabetes and direct application of paper-based technology to the human body fluids. |
| Keyword | Tear glucose, Paper microfluidics, Preconcentration, Schirmer strip, Diabetes diagnosis |
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