| Info. | Vol.11 - No.4 (2017.12.20) |
|---|---|
| Title | Multi-electrochemical Signal Generation using Metalloprotein Based on Selective Surface Modification |
| Authors | Yong-Ho Chung2, Si-Youl Yoo1, Jinho Yoon1, Junhong Min3 and Jeong-Woo Choi1,* |
| Institutions | 1Department of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 04107, Republic of Korea 2Department of Chemical Engineering, Hoseo University, Baebang, Asan, Chungnam 31499, Republic of Korea 3School of Integrative Engineering, Chung-Ang University, Heukseokdong, Dongjak-gu, Seoul 06974, Republic of Korea *Correspondence and requests for materials should be addressed to J.-W. Choi ( jwchoi@sogang.ac.kr) |
| Abstract | In this research, we demonstrate a simple method to generate a multi-peak in a single electrochemical signal for the application to bioelectronics devices. Myoglobin is used as a source of electrochemical signal, and its property of redox peak is controlled by the introduction of various chemical-linking materials. Based on controlled signals of myoglobin, multisignal having dual peak is achieved by the signal combination of six electrodes, which have different electrochemical signals by the modification of each electrode with different kinds of chemical linkers individually. For the device formation, selective immobilization process was performed by using reductive cleavage of pre-immobilized thiol group. As a result, the proposed concept shows simple and effective formation of a multi-signal in a single electrochemical signal as compared with other methods based on heterolayer and hybrid materials, and it can be directly applied to materialize practical bioelectronic devices such as a bio-logic gate or bio-computing system |
| Keyword | Metalloprotein, Cyclic voltammetry, Multisignal, Selective immobilization |
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