| Info. | Vol.12 - No.2 (2018.06.20) |
|---|---|
| Title | Immuno-Nanoparticles for Multiplex Protein Imaging in Cells and Tissues |
| Authors | Hawon Lee1, Xiaohu Gao2,* & Young-Pil Kim1,3,4,* |
| Institutions | 1Deparment of Life Science, Hanyang University, Seoul 04763, Republic of Korea 2Department of Bioengineering, University of Washington, Seattle, WA 98195, USA 3Research Institute for Natural Sciences, Hanyang University, Seoul 04763, Republic of Korea 4Institute of Nano Science and Technology, Hanyang University, Seoul 04763, Republic of Korea *Correspondence and requests for materials should be addressed to X. Gao (xgao@uw.edu) and Y.-P. Kim (ypilkim@hanyang.ac.kr) |
| Abstract | Simultaneous visualization of numerous proteins in cells and tissues is fundamental for understanding their diversity and dynamics and to address the heterogeneity of human diseases. Despite the many advantages of multiplex analysis, current methods typically rely upon immunohistochemistry, which can only be used to detect a few proteins. The exceptional optical properties of nanoparticles (NPs) have improved multiplex imaging in cells and tissues. Here, we review recent advances in multiplex imaging-based molecular diagnosis using antibody-conjugated NPs (immuno-NPs). With the aim of furthering development, we anticipate that NP-based multiplex imaging techniques will complement classical immunohistochemistry methods and provide insight into the biological diversity of cells and tissues. |
| Keyword | Multiplex, Imaging, Antibody, Nanoparticle, Quantum dot, SERS |
| PDF File |
 # 2010년도 발행분 부터는 Springer 의 BioChip Journal 페이지에서 전문을 열람하실 수 있습니다.
# 학회회원 로그인 후 [ Springer BioChip Journal 열람하기 ] 버튼을 클릭하시면 새창으로 열립니다. |
