| Info. | Vol.14 - No.3 (2020.09.20) |
|---|---|
| Title | Flexible Chemical Sensors Using Signal Generation from Cyclodextrin-Analyte Interactions on Polymer Composites |
| Authors | Joonwon Bae 1,*,†, Dong-Sik Shin2,†, Ji-Hwan Ha3, Yunjung Hwang1,4, Chang-Soo Lee4,5, Hye Jun Kim1, Ayeon Jang1 & Sung-Hoon Park 3,* |
| Institutions | "1Department of Applied Chemistry, Dongduk Women’s University, Seoul 02748, Republic of Korea 2Department of Chemical and Biological Engineering, Sookmyung Women’s University, Seoul 04310, Republic of Korea 3Department of Mechanical Engineering, Soongsil University, Seoul 06978, Republic of Korea 4Bionanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), 125 Gwahak-Ro, Yuseong-Gu, Daejeon 34141, Republic of Korea 5Department of Biotechnology, University of Science & Technology (UST), 125 Gwahak-Ro, Yuseong-Gu, Daejeon 34141, Republic of Korea †These authors contributed equally. *Correspondence and requests for materials should be addressed to S.H. Park (leopark@ssu.ac.kr) and J.W. Bae (redsox7@dongduk.ac.kr ; joonwonbae@gmail.com) |
| Abstract | We present the design of a chemical sensor and study the generation of electrical signals produced by the formation of a cyclodextrin inclusion complex. Flexible poly(dimethylsiloxane)/graphene hybrid composites were used as sensor substrates and sensing media, beta-cyclodextrin (beta-CD) molecules were incorporated using simple bio-coupling reactions. The feasibility of sensing molecules through the formation of beta-CD/analyte inclusion complexes was investigated systematically using direct electrical measurement. The acquisition and transduction of electrical signals generated by inclusion complex formation is a central focus of this study and extensive complementary experiments were carried out to characterize this phenomenon. Because it is useful for development of a sort of sensor system, electrical measurements were performed to measure the sensitivity of this system (10 nM). However, more study is required to determine the selectivity. This article will be a useful reference for the design of versatile chemical sensors utilizing a non-toxic sensing medium on flexible composite substrates. |
| Keyword | Flexible sensor, cyclodextrin, inclusion complex, poly(dimethylsiloxane), graphene |
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